SYUNIK, Armenia — A small hotel in Goris, a sleepy tourist resort in the Syunik region in southern Armenia, seems an unlikely backdrop for geopolitical maneuvers between Western powers, Turkey, Russia and Iran. But that is what the Hotel Mirhav, a trio of rustic cottages filled with antique kilims and copperware, has become amid fears of renewed conflict between Armenia and Azerbaijan from which Iran could emerge the biggest loser.

Numerous families have been sheltering here since Dec. 12, when Azerbaijan effectively cut off access to their native Nagorno-Karabakh, letting a group of self-described Azerbaijani “eco-activists” with no history of environmental advocacy barge through Russian peacekeepers to block the sole road linking the disputed enclave to Armenia.

The Armenian-majority region lies within Azerbaijan’s internationally recognized borders but has governed itself under the name of the Republic of Artsakh since the collapse of the Soviet Union.

As regional powers butt heads, a full-blown humanitarian crisis is unfolding, with baby formula, medicines and other vital supplies growing scarcer by the day. Schools have been shuttered and Nagorno-Karabakh’s 120,000 inhabitants put on ration cards as Azerbaijan continues to disrupt gas and electricity supplies amid sub-zero temperatures. Armenia’s leaders accuse Azerbaijan of seeking to ethnically cleanse Nagorno-Karabakh by starving the local population and forcing it to leave.